The explosion at the Port Authority Bus Terminal subway station snarled the Monday morning rush for thousands of commuters.
1, 2, 3, A, C, E, N, Q, R, W and 7 trains were all bypassing 42nd Street as police investigate, according to the MTA.
A and C trains were stopping along the D line between West 4th Street-Washington Square and 59th Street-Columbus Circle.
B service is suspended between Bedford Park Boulevard and Brighton Beach.
New Jersey Transit commuter trains running into Penn Station along the Northeast Corridor Line, North Jersey Coast Line and Main/Bergen-Port Jervis Line are also delayed, and at least two trains have already been canceled, the agency reported.
Buses from New Jersey are dropping off at 40th Street and 10th Avenue rather than Port Authority, Fox 5 reported.